Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599506 | 0.80 | MAOA (0.43) | MAOAMAOBMAPKAPK2NPC1LMNA | |
| SCHEMBL11127249 | 0.79 | MAOA (0.53) | MAOAMAOBMAPKAPK2NPC1LMNA | |
| SCHEMBL28660534 | 0.77 | MAOA (0.40) | MAOAMAOBMAPKAPK2 | |
| SCHEMBL30770347 | 0.77 | MAOA (0.40) | MAOAMAOBMAPKAPK2 | |
| SCHEMBL11297104 | 0.77 | MAOA (0.40) | MAOAMAOBMAPKAPK2 | |
| SCHEMBL30168142 | 0.76 | MAOA (0.46) | MAOAMAOBMAPKAPK2NPC1LMNA | |
| SCHEMBL2658102 | 0.76 | MAOA (0.46) | MAOAMAOBMAPKAPK2NPC1LMNA | |
| SCHEMBL115187 | 0.71 | MAOA (0.50) | MAOAMAOBMAPKAPK2NPC1LMNA | |
| SCHEMBL29490369 | 0.68 | MAOA (0.55) | MAOAMAOBMAPKAPK2NPC1LMNA | |
| SCHEMBL367138 | 0.68 | MAOA (0.55) | MAOAMAOBMAPKAPK2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395555-A1 | 4-(PHENYL-(PIPERIDIN-4-YL)-AMINO)-BENZAMIDE DERATIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, ANXIETY OR GASTROINTESTINAL DISORDERS | AstraZeneca AB (SE) | 2004-03-10 | — | — | EP | disclosed |
| EP-1395557-A1 | 4-(phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | AstraZeneca AB (SE) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002094785-A1 | 4-(phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2002-11-28 | — | — | WO | disclosed |
| WO-2002094782-A1 | 4-(PHENYL-(PIPERIDIN-4-YL)-AMINO)-BENZAMIDE DERATIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, ANXIETY OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2002-11-28 | — | — | WO | disclosed |