Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 3/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CTSG | P08311 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600360 | 1.00 | ALDH1A1 (0.34) | ALDH1A1TSHRGAAL3MBTL1THRB | |
| SCHEMBL6858805 | 1.00 | ALDH1A1 (0.34) | ALDH1A1TSHRGAAL3MBTL1THRB | |
| SCHEMBL6601584 | 0.93 | ALDH1A1 (0.40) | ALDH1A1TSHRL3MBTL1THRBATM | |
| SCHEMBL6601571 | 0.93 | ALDH1A1 (0.40) | ALDH1A1TSHRL3MBTL1THRBATM | |
| SCHEMBL6601578 | 0.93 | ALDH1A1 (0.40) | ALDH1A1TSHRL3MBTL1THRBATM | |
| SCHEMBL6602867 | 0.89 | SMN1; SMN2 (0.38) | ALDH1A1TSHRGAAHTTKMT2A | |
| SCHEMBL6602871 | 0.89 | SMN1; SMN2 (0.38) | ALDH1A1TSHRGAAHTTKMT2A | |
| SCHEMBL6860046 | 0.89 | SMN1; SMN2 (0.39) | ALDH1A1TSHRL3MBTL1ATMHSD17B10 | |
| SCHEMBL6600510 | 0.89 | SMN1; SMN2 (0.39) | ALDH1A1TSHRL3MBTL1ATMHSD17B10 | |
| SCHEMBL6600514 | 0.89 | SMN1; SMN2 (0.39) | ALDH1A1TSHRL3MBTL1ATMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6794523-B2 | ANTICANCER AGENTS, ANTITUMOR AGENTS; LEUKEMIA | FLORIDA STATE UNIVERSITY | 2004-09-21 | — | — | US | disclosed |
| EP-0667772-B9 | TAXANES HAVING AN ALKYL SUBSTITUTED SIDE-CHAIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | UNIV FLORIDA STATE (US) | 2004-08-04 | — | — | EP | disclosed |
| US-20030187061-A1 | Antitumor agnets; antileukemia agents | FLORIDA STATE UNIVERSITY | 2003-10-02 | — | — | US | disclosed |
| EP-0667772-B1 | TAXANES HAVING AN ALKYL SUBSTITUTED SIDE-CHAIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | UNIV FLORIDA STATE (US) | 2003-05-14 | — | — | EP | disclosed |
| US-20030065200-A1 | Anticancer agents, antitumor agents; leukemia | FLORIDA STATE UNIVERSITY | 2003-04-03 | — | — | US | disclosed |
| US-6521660-B2 | Anticancer, antitumor agents | FLORIDA STATE UNIVERSITY | 2003-02-18 | — | — | US | disclosed |
| US-20020147335-A1 | Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them | FLORIDA STATE UNIVERSITY | 2002-10-10 | — | — | US | disclosed |
| US-6335362-B1 | ANTITUMOR AND ANTICARCINOGENIC AGENTS FOR LEUKEMIA | FLORIDA STATE UNIVERSITY | 2002-01-01 | — | — | US | disclosed |
| US-6018073-A | Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them | FLORIDA STATE UNIVERSITY (US) | 2000-01-25 | — | — | US | disclosed |
| US-5739362-A | ANTILEUKEMIA, ANTITUMOR AGENTS | FLORIDA STATE UNIVERSITY (US) | 1998-04-14 | — | — | US | disclosed |
| EP-0667772-A4 | TAXANES HAVING AN ALKYL SUBSTITUTED SIDE-CHAIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | UNIV FLORIDA STATE (US) | 1995-12-20 | — | — | EP | disclosed |
| EP-0667772-A1 | TAXANES HAVING AN ALKYL SUBSTITUTED SIDE-CHAIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FLORIDA STATE UNIVERSITY (US) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994010997-A1 | TAXANES HAVING AN ALKYL SUBSTITUTED SIDE-CHAIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FLORIDA STATE UNIVERSITY (US) | 1994-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065200-A1 | Anticancer agents, antitumor agents; leukemia | MCL1, BCL3, TOP2A | ALDH1A1 932/4885TSHR 3453/4885GAA 716/4885 |
| US-20030187061-A1 | Antitumor agnets; antileukemia agents | MCL1, TP53, EWSR1 | ALDH1A1 2220/4885TSHR 2790/4885GAA 1745/4885 |
| US-20020147335-A1 | Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them | TOP2A, TOP2B, TUBB3 | ALDH1A1 648/4885TSHR 3339/4885GAA 3848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.