Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3357000 | 0.72 | DPP4 (0.38) | HSD11B1 | |
| SCHEMBL9682670 | 0.72 | ALDH1A1 (0.43) | GRIN1GRIN2AGRIN2BOPRM1OPRD1 | |
| SCHEMBL30825707 | 0.68 | GRIN1 (0.58) | GRIN1GRIN2AGRIN2BOPRM1OPRD1 | |
| SCHEMBL30825709 | 0.68 | GRIN1 (0.58) | GRIN1GRIN2AGRIN2BOPRM1OPRD1 | |
| SCHEMBL30825701 | 0.68 | GRIN1 (0.58) | GRIN1GRIN2AGRIN2BOPRM1OPRD1 | |
| SCHEMBL27451854 | 0.68 | GRIN1 (0.58) | GRIN1GRIN2AGRIN2BOPRM1OPRD1 | |
| SCHEMBL13330626 | 0.67 | GRIN1 (0.49) | GRIN1GRIN2AGRIN2BOPRM1OPRD1 | |
| SCHEMBL9683265 | 0.67 | GRIN1 (0.39) | GRIN1GRIN2AGRIN2BOPRM1OPRD1 | |
| SCHEMBL30731373 | 0.64 | GRIN1 (0.45) | GRIN1GRIN2AGRIN2BOPRM1OPRD1 | |
| SCHEMBL29980976 | 0.63 | OPRM1 (0.57) | GRIN1GRIN2AGRIN2BOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373258-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | Pfizer Products Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002060896-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER PRODUCTS INC. (US) | 2002-08-08 | — | — | WO | disclosed |