Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
| ▸ | COMT | P21964 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15074578 | 0.94 | HPGDS (0.68) | HPGDSPOLBRAB9ACYP2A6ADORA3 | |
| SCHEMBL2837433 | 0.81 | HPGDS (0.87) | HPGDSPOLBRAB9AADORA3ALOX15 | |
| SCHEMBL1230353 | 0.78 | RAB9A (1.00) | HPGDSPOLBRAB9AADORA3ALOX15 | |
| SCHEMBL15074574 | 0.78 | HPGDS (0.48) | HPGDSPOLBRAB9ACYP2A6BIRC5 | |
| SCHEMBL2838459 | 0.78 | HPGDS (1.00) | HPGDSPOLBRAB9AADORA3ALOX15 | |
| SCHEMBL2662870 | 0.78 | RAB9A (0.70) | HPGDSPOLBRAB9AADORA3ALOX15 | |
| SCHEMBL15070812 | 0.77 | L3MBTL1 (0.57) | RAB9ACYP2A6BIRC5PDGFRBPDGFRA | |
| SCHEMBL1854414 | 0.77 | PDGFRB (0.49) | HPGDSPOLBCYP2A6BIRC5PDGFRB | |
| SCHEMBL708999 | 0.76 | PDGFRB (0.75) | RAB9ACYP2A6BIRC5PDGFRBPDGFRA | |
| SCHEMBL17279801 | 0.76 | RAB9A (0.96) | HPGDSPOLBRAB9AADORA3ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373263-B1 | HETEROCYCLIC COMPOUNDS FOR AGING-RELATED AND DIABETIC VASCULAR COMPLICATIONS | TORRENT PHARMACEUTICALS LTD (IN) | 2004-10-27 | — | — | EP | claimed |
| CN-1259316-C | Heterocyclic compounds for age-related and diabetic vascular system complications | TORRENTAU PHARMACEUTICAL LTD (IN) | 2006-06-14 | — | — | CN | disclosed |
| CN-1498217-A | Heterocyclic compounds for aging-related and diabetic vascular complications | ������˹ҩƷ��˾ | 2004-05-19 | — | — | CN | disclosed |