Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 12/20 | 0.60 |
| ▸ | HTR1A | P08908 | 11/20 | 0.60 |
| ▸ | DRD4 | P21917 | 9/20 | 0.60 |
| ▸ | DRD3 | P35462 | 8/20 | 0.60 |
| ▸ | DRD2 | P14416 | 9/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625410 | 0.89 | DRD2 (0.73) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6600206 | 0.88 | DRD2 (0.71) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6953494 | 0.88 | DRD2 (0.73) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6601681 | 0.86 | DRD2 (0.70) | HTR1BHTR1ADRD2HTR2AHTR6 | |
| SCHEMBL6603834 | 0.86 | DRD2 (0.71) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6597267 | 0.85 | DRD2 (0.72) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6625693 | 0.84 | HTR1B (0.61) | HTR1BHTR1ADRD4DRD3DRD2 | |
| SCHEMBL6598945 | 0.84 | DRD2 (0.47) | HTR1BDRD2HTR2AHTR6 | |
| SCHEMBL6600673 | 0.84 | KCNH2 (0.52) | — | |
| SCHEMBL6600317 | 0.84 | HTR1B (0.63) | HTR1BHTR1ADRD4DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478643-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H. Lundbeck A/S (DK) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003070723-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2003-08-28 | — | — | WO | disclosed |