Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14406151 | 0.90 | GPR119 (0.47) | GPR119ALDH1A1LMNASCN9A | |
| SCHEMBL6598945 | 0.86 | DRD2 (0.47) | KCNH2ALDH1A1LMNAPOLBCYP3A4 | |
| SCHEMBL19972594 | 0.86 | GPR119 (0.50) | TP53GPR119ALDH1A1LMNAPOLB | |
| SCHEMBL6966415 | 0.84 | GPR119 (0.47) | KCNH2GPR119 | |
| SCHEMBL6600804 | 0.84 | HTR1B (0.60) | — | |
| SCHEMBL6601681 | 0.82 | DRD2 (0.70) | GPR119POLB | |
| SCHEMBL6600206 | 0.82 | DRD2 (0.71) | GPR119 | |
| SCHEMBL558066 | 0.82 | SCN9A (0.61) | TP53GPR119MEN1KMT2ASCN9A | |
| SCHEMBL6603834 | 0.81 | DRD2 (0.71) | GPR119POLB | |
| SCHEMBL27322905 | 0.81 | SCN9A (0.50) | GPR119MEN1KMT2ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478643-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H. Lundbeck A/S (DK) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003070723-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2003-08-28 | — | — | WO | disclosed |