Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600673 | 0.86 | KCNH2 (0.52) | POLBKCNH2ALDH1A1LMNACYP3A4 | |
| SCHEMBL6966415 | 0.86 | GPR119 (0.47) | DRD2HTR1BHTR6KCNH2 | |
| SCHEMBL6601681 | 0.84 | DRD2 (0.70) | DRD2HTR1BHTR6POLBHTR2A | |
| SCHEMBL6600804 | 0.84 | HTR1B (0.60) | DRD2HTR1BHTR6HTR2A | |
| SCHEMBL6603834 | 0.83 | DRD2 (0.71) | DRD2HTR1BHTR6POLBHTR2A | |
| SCHEMBL12127417 | 0.83 | SCN9A (0.57) | DRD2 | |
| SCHEMBL6597267 | 0.83 | DRD2 (0.72) | DRD2HTR1BHTR6HTR2A | |
| SCHEMBL6625693 | 0.82 | HTR1B (0.61) | DRD2HTR1BHTR6HTR2A | |
| SCHEMBL6953494 | 0.82 | DRD2 (0.73) | DRD2HTR1BHTR6HTR2A | |
| SCHEMBL6600206 | 0.82 | DRD2 (0.71) | DRD2HTR1BHTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478643-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H. Lundbeck A/S (DK) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003070723-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2003-08-28 | — | — | WO | disclosed |
| EP-0575430-B1 | PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF ADDICTION TO DRUGS AND SUBSTANCES OF ABUSE | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | disclosed |
| EP-0575429-B1 | TREATMENT OF COGNITIVE DISORDERS | LUNDBECK & CO AS H (DK) | 1995-12-06 | — | — | EP | disclosed |
| US-5462948-A | Treatment of addiction to drugs and substances of abuse | H. LUNDBECK A/S (DK) | 1995-10-31 | — | — | US | disclosed |
| US-5444073-A | Administering 1-aryl-3-(4-piperidyl)-indole derivatives | H. LUNDBECK A/S (DK) | 1995-08-22 | — | — | US | disclosed |
| US-5439922-A | Administering dopamine antagonists having reduced side effects | H. LUNDBECK A/S (DK) | 1995-08-08 | — | — | US | disclosed |
| EP-0533824-B1 | PIPERIDYL-SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 1994-11-09 | — | — | EP | disclosed |