Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 2/20 | 0.34 |
| ▸ | SAT1 | P21673 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4527984 | 0.82 | MEN1 (0.42) | EP300TSHRMEN1TP53CYP3A4 | |
| SCHEMBL1967142 | 0.74 | HTR2A (0.56) | ADRA1DADRA1AADRA1BMAPTHTR2A | |
| SCHEMBL1967205 | 0.73 | ALDH1A1 (0.52) | ADRA1DADRA1AADRA1BKDM4EALDH1A1 | |
| SCHEMBL1967608 | 0.71 | NPC1 (0.46) | ADRA1DADRA1AADRA1BTSHRALDH1A1 | |
| SCHEMBL5127860 | 0.71 | ADRA1D (0.40) | ADRA1DADRA1AADRA1BSAT1ALDH1A1 | |
| SCHEMBL25343202 | 0.71 | GFER (0.46) | ADRA1DADRA1AADRA1BKDM4EALDH1A1 | |
| SCHEMBL1968986 | 0.71 | L3MBTL1 (0.50) | ADRA1DADRA1AADRA1BSAT1ALDH1A1 | |
| SCHEMBL1969046 | 0.71 | TAAR1 (0.50) | KDM4EALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2406756 | 0.71 | KMT2A (0.51) | ALDH1A1MEN1CYP2D6CYP2C19KMT2A | |
| SCHEMBL2006207 | 0.71 | CNR2 (0.43) | CNR2ALDH1A1MAPTNAAAALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgen Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003009850-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC. (US) | 2003-02-06 | — | — | WO | disclosed |