Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | TACR2 | P21452 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951612 | 0.88 | TACR3 (0.47) | PDE10ATSHRTACR3LMNATACR2 | |
| Hydrochloric Acid SCHEMBL7077944 | 0.87 | TACR3 (0.47) | PDE10ATSHRTACR3LMNATACR2 | |
| SCHEMBL6582324 | 0.82 | DHODH (0.42) | PDE10ATSHRTACR3LMNATACR2 | |
| SCHEMBL6586109 | 0.80 | TRPV4 (0.43) | PDE10ATSHRTACR3LMNATACR2 | |
| SCHEMBL6340547 | 0.80 | TACR3 (0.40) | PDE10ATSHRTACR3LMNATACR2 | |
| SCHEMBL7159967 | 0.79 | DHODH (0.46) | TACR3LMNATACR2OPRM1DHODH | |
| SCHEMBL7076610 | 0.79 | DHODH (0.48) | PDE10ATSHRTACR3LMNATACR2 | |
| SCHEMBL7080701 | 0.79 | LMNA (0.50) | TACR3LMNATACR2OPRM1KCNH2 | |
| SCHEMBL2372430 | 0.79 | TACR3 (0.50) | TACR3TACR2OPRM1POLBKCNH2 | |
| SCHEMBL6627076 | 0.78 | TACR3 (0.38) | TACR3LMNATACR2OPRM1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377555-A1 | NOVEL COMPOUNDS | GlaxoSmithKline S.p.A. (IT) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002083645-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE S.P.A. (IT) | 2002-10-24 | — | — | WO | disclosed |