Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601206 | 0.93 | ITGB3 (0.51) | ITGB3ITGA2BSIGMAR1GRM2PRSS1 | |
| SCHEMBL6605691 | 0.93 | ITGB3 (0.51) | ITGB3ITGA2BSIGMAR1POLBSLC6A4 | |
| SCHEMBL6600978 | 0.92 | ITGB3 (0.46) | ITGB3ITGA2BSIGMAR1GRM2PRSS1 | |
| SCHEMBL6601180 | 0.91 | ITGB3 (0.45) | ITGB3ITGA2BSIGMAR1POLBSLC6A4 | |
| SCHEMBL6600555 | 0.90 | ITGB3 (0.43) | ITGB3ITGA2BSIGMAR1GRM2DRD3 | |
| SCHEMBL6604885 | 0.89 | ITGB3 (0.41) | ITGB3ITGA2BSIGMAR1POLBSLC6A2 | |
| SCHEMBL6603919 | 0.88 | ITGB3 (0.42) | ITGB3ITGA2BSIGMAR1POLBSLC6A4 | |
| SCHEMBL6602885 | 0.88 | ITGB3 (0.42) | ITGB3ITGA2BSIGMAR1POLBSLC6A4 | |
| SCHEMBL6600829 | 0.88 | ITGB3 (0.45) | ITGB3ITGA2BSIGMAR1GRM2PRSS1 | |
| SCHEMBL6600939 | 0.87 | ITGB3 (0.50) | ITGB3ITGA2BSIGMAR1GRM2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741133-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| EP-0741133-A2 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-11-06 | — | — | EP | disclosed |