Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.65 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4514452 | 0.82 | CHRM2 (0.56) | AOC3TAAR1CHRM2BCHECHRM1 | |
| SCHEMBL2937482 | 0.82 | AOC3 (0.73) | AOC3TAAR1SIGMAR1CHRM2BCHE | |
| Hydrochloric Acid SCHEMBL8509376 | 0.80 | AOC3 (0.71) | AOC3TAAR1SIGMAR1CHRM2BCHE | |
| SCHEMBL6601575 | 0.77 | AOC3 (0.67) | AOC3TAAR1SIGMAR1CHRM2BCHE | |
| SCHEMBL28858018 | 0.77 | TAAR1 (0.75) | AOC3TAAR1SIGMAR1CHRM2CHRM1 | |
| SCHEMBL8507656 | 0.74 | TAAR1 (0.60) | AOC3TAAR1SIGMAR1CHRM2CHRM1 | |
| SCHEMBL23925502 | 0.73 | AOC3 (0.61) | AOC3TAAR1SIGMAR1CHRM2BCHE | |
| SCHEMBL6272891 | 0.73 | AOC3 (0.61) | AOC3TAAR1SIGMAR1CHRM2BCHE | |
| SCHEMBL13579948 | 0.73 | BCHE (0.69) | AOC3SIGMAR1CHRM2BCHEABCB1 | |
| SCHEMBL1965745 | 0.73 | AOC3 (0.61) | AOC3TAAR1SIGMAR1CHRM2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgen Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003009850-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC. (US) | 2003-02-06 | — | — | WO | disclosed |