Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.64 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11989507 | 0.86 | LTA4H (0.61) | PRMT6LTA4HFFAR1CYP17A1CYP11B1 | |
| SCHEMBL158066 | 0.82 | PRMT6 (0.68) | PRMT6LTA4HFFAR1CYP17A1CYP11B1 | |
| SCHEMBL197793 | 0.81 | GGPS1 (0.44) | PRMT6 | |
| SCHEMBL21408614 | 0.79 | PRMT6 (0.64) | PRMT6LTA4HFFAR1CYP17A1CYP11B1 | |
| SCHEMBL477487 | 0.79 | PRMT6 (0.63) | PRMT6LTA4HFFAR1CYP17A1CYP11B1 | |
| SCHEMBL4171352 | 0.79 | PRMT6 (0.63) | PRMT6LTA4HFFAR1CYP17A1CYP11B1 | |
| SCHEMBL7499623 | 0.79 | PRMT6 (0.63) | PRMT6LTA4HFFAR1CYP17A1CYP11B1 | |
| SCHEMBL111078 | 0.79 | LTA4H (0.72) | PRMT6LTA4HFFAR1CYP17A1CYP11B1 | |
| SCHEMBL5018750 | 0.78 | PRMT6 (0.62) | PRMT6LTA4HFFAR1CYP17A1CYP11B1 | |
| SCHEMBL8212414 | 0.78 | PRMT6 (0.62) | PRMT6LTA4HFFAR1CYP17A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411933-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SmithKline Beecham Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003013518-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |