Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.59 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.59 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602021 | 0.92 | ITGB3 (0.53) | ITGB3ITGA2BGRM2SIGMAR1 | |
| SCHEMBL6600939 | 0.92 | ITGB3 (0.50) | ITGB3ITGA2BGRM2SIGMAR1PRSS1 | |
| Gantofiban SCHEMBL6602032 | 0.91 | ITGB3 (0.70) | ITGB3ITGA2BGRM2SIGMAR1PRSS1 | |
| Gantofiban SCHEMBL6600995 | 0.91 | ITGB3 (0.70) | ITGB3ITGA2BGRM2SIGMAR1PRSS1 | |
| Gantofiban SCHEMBL6600994 | 0.91 | ITGB3 (0.70) | ITGB3ITGA2BGRM2SIGMAR1PRSS1 | |
| SCHEMBL6600475 | 0.91 | ITGB3 (0.52) | ITGB3ITGA2BGRM2SIGMAR1PRSS1 | |
| SCHEMBL6603247 | 0.90 | ITGB3 (0.54) | ITGB3ITGA2BGRM2SIGMAR1PRSS1 | |
| SCHEMBL6601152 | 0.90 | ITGB3 (0.52) | ITGB3ITGA2BGRM2SIGMAR1PRSS1 | |
| SCHEMBL6602820 | 0.90 | ITGB3 (0.59) | ITGB3ITGA2BGRM2SIGMAR1PRSS1 | |
| SCHEMBL6606673 | 0.89 | ITGB3 (0.56) | ITGB3ITGA2BGRM2SIGMAR1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741133-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| EP-0741133-A2 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-11-06 | — | — | EP | disclosed |