Sugi Predict

Sugi Predict / Compounds / SCHEMBL660178

SCHEMBL660178

SCHEMBL660178

O=C(O)C=Cc1ccoc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HCAR2 Q8TDS4 4/20 1.00
▸ MAPT P10636 4/20 0.56
▸ ALDH1A1 P00352 3/20 0.56
▸ HDAC3 O15379 2/20 0.54
▸ HDAC4 P56524 2/20 0.54
▸ HDAC1 Q13547 2/20 0.54
▸ HDAC7 Q8WUI4 2/20 0.54
▸ HDAC2 Q92769 2/20 0.54
▸ HDAC10 Q969S8 2/20 0.54
▸ HDAC11 Q96DB2 2/20 0.54
▸ HDAC8 Q9BY41 2/20 0.54
▸ HDAC6 Q9UBN7 2/20 0.54
▸ HDAC9 Q9UKV0 2/20 0.54
▸ HDAC5 Q9UQL6 2/20 0.54
▸ TNKS O95271 1/20 0.54
▸ TNKS2 Q9H2K2 1/20 0.54
▸ CA12 O43570 2/20 0.50
▸ AKR1B10 O60218 2/20 0.50
▸ CA1 P00915 2/20 0.50
▸ CA2 P00918 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL564789 1.00 HCAR2 (1.00) HCAR2MAPTALDH1A1HDAC3HDAC4
SCHEMBL7893859 1.00 HCAR2 (1.00) HCAR2MAPTALDH1A1HDAC3HDAC4
Hydrochloric Acid SCHEMBL9261463 0.98 HCAR2 (0.96) HCAR2MAPTALDH1A1HDAC3HDAC4
SCHEMBL10862371 0.89 HCAR2 (0.80) HCAR2MAPTALDH1A1HDAC3HDAC4
SCHEMBL7827422 0.83 HCAR2 (0.69) HCAR2MAPTALDH1A1HDAC3HDAC4
SCHEMBL9062121 0.83 HCAR2 (0.69) HCAR2MAPTALDH1A1HDAC3HDAC4
SCHEMBL9062123 0.83 HCAR2 (0.69) HCAR2MAPTALDH1A1HDAC3HDAC4
SCHEMBL7827419 0.83 HCAR2 (0.69) HCAR2MAPTALDH1A1HDAC3HDAC4
SCHEMBL6832853 0.82 HCAR2 (0.69) HCAR2MAPTALDH1A1PKMALOX5
SCHEMBL13692335 0.82 HCAR2 (0.69) HCAR2MAPTALDH1A1PKMALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 296 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 — — EP claimed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 — — WO claimed
CN-117986702-A Preparation method of carboxyl polysulfide modified rubber composite material 沈阳化工大学 2024-05-07 — — CN claimed
CN-115521318-B Preparation method of nalfurorphine diastereoisomer impurity 南京海纳医药科技股份有限公司 2024-04-16 — — CN claimed
CN-111518061-B Preparation method of (E) -3- (3-furyl) acrylic acid 鲁南制药集团股份有限公司 2023-08-25 — — CN claimed
CN-115521318-A Preparation method of nalfuraphten diastereoisomer impurity 南京海纳医药科技股份有限公司 2022-12-27 — — CN claimed
CN-112708056-B Viscosity-reducing polycarboxylate superplasticizer for concrete member and preparation method thereof 科之杰新材料集团河南有限公司 2022-10-18 — — CN claimed
CN-114621238-A Method for preparing nafrafine 鲁南制药集团股份有限公司 2022-06-14 — — CN claimed
CN-114015245-A Stable rubber powder polymer composite modified asphalt and mixture 鄂尔多斯市路泰公路工程有限责任公司 2022-02-08 — — CN claimed
CN-112708056-A Viscosity-reducing polycarboxylate superplasticizer for concrete member and preparation method thereof 科之杰新材料集团河南有限公司 2021-04-27 — — CN claimed
US-20040206631-A1 Plating bath and method for depositing a metal layer on a substrate SHIPLEY COMPANY, L.L.C. 2004-10-21 — — US claimed
EP-0688210-B1 USE OF CARNOSINE IN COMBINATION WITH UROCANIC ACID FOR TREATMENT OF PHOTODERMATOSES BEIERSDORF AG (DE) 2004-02-25 — — EP claimed
US-20030082830-A1 Synthesis of combinatorial libraries of compounds reminiscent of natural products NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-05-01 — — US claimed
EP-1300488-A2 Plating path and method for depositing a metal layer on a substrate Shipley Co. L.L.C. (US) 2003-04-09 — — EP claimed
US-6448443-B1 GENERATED FROM DIVERSIFIABLE SCAFFOLDS SYNTHESIZED FROM THE PYRIDINE-BASED TEMPLATE ISONICOTINAMIDE; ALSO PROVIDES A NOVEL ORTHO-NITROBENZYL PHOTOLINKER; SYNTHESIZED FROM A SHIKIMIC ACID BASED EPOXYOL TEMPLATE PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2002-09-10 — — US claimed
WO-2000006525-A9 SYNTHESIS OF COMBINATORIAL LIBRARIES OF COMPOUNDS REMINISCENT OF NATURAL PRODUCTS HARVARD COLLEGE (US) 2000-04-20 — — WO claimed
WO-2000006525-A2 SYNTHESIS OF COMBINATORIAL LIBRARIES OF COMPOUNDS REMINISCENT OF NATURAL PRODUCTS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2000-02-10 — — WO claimed
US-5939268-A DIELS-ALDER REACTION PRODUCT OF A DIENE AND A DIENOPHILE; CHEMICAL INTERMEDIATES FOR DRUGS, SOLID PHASE SYNTHESIS THE SCRIPPS RESEARCH INSTITUTE (US) 1999-08-17 — — US claimed
EP-0773953-A1 COMBINATORIAL LIBRARIES OF MOLECULES AND METHODS FOR PRODUCING SAME THE SCRIPPS INSTITUTE (US) 1997-05-21 — — EP claimed
WO-1996003424-A1 COMBINATORIAL LIBRARIES OF MOLECULES AND METHODS FOR PRODUCING SAME THE SCRIPPS RESEARCH INSTITUTE (US) 1996-02-08 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030082830-A1 Synthesis of combinatorial libraries of compounds reminiscent of natural products TKFC, NISCH, PTGIS HCAR2 219/4885MAPT 1830/4885ALDH1A1 568/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.