Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 13/20 | 0.52 |
| ▸ | KIT | P10721 | 9/20 | 0.51 |
| ▸ | FLT3 | P36888 | 8/20 | 0.51 |
| ▸ | FLT1 | P17948 | 6/20 | 0.51 |
| ▸ | LCK | P06239 | 6/20 | 0.51 |
| ▸ | LYN | P07948 | 6/20 | 0.51 |
| ▸ | FLT4 | P35916 | 6/20 | 0.51 |
| ▸ | BLK | P51451 | 6/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.51 |
| ▸ | CSF1R | P07333 | 5/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.51 |
| ▸ | FYN | P06241 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260583 | 0.92 | KDR (0.55) | MEN1MAPTHTTRAB9AKMT2A | |
| SCHEMBL4260556 | 0.83 | RIPK2 (0.53) | MEN1KMT2AKDRLCKSRC | |
| SCHEMBL6614917 | 0.81 | RIPK2 (0.51) | MEN1KMT2AKDRKITFLT3 | |
| SCHEMBL6614602 | 0.81 | RIPK2 (0.50) | KDRKITFLT3FLT1LCK | |
| SCHEMBL4257173 | 0.80 | KDR (0.58) | MEN1MAPTHTTRAB9AKMT2A | |
| SCHEMBL6613292 | 0.79 | KDR (0.55) | MEN1MAPTHTTRAB9AKMT2A | |
| SCHEMBL4261925 | 0.79 | RIPK2 (0.69) | KDRFLT3FLT1LCKAURKB | |
| SCHEMBL4258858 | 0.79 | RET (0.55) | KDRKITFLT3FLT1LCK | |
| SCHEMBL4255774 | 0.78 | RIPK2 (0.59) | MEN1KMT2AKDRKITFLT3 | |
| SCHEMBL4262663 | 0.78 | RIPK2 (0.58) | KDRFLT1LCKNTRK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436265-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-12-15 | — | — | EP | claimed |
| EP-1436265-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2004-07-14 | — | — | EP | claimed |
| WO-2003072541-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-04 | — | — | WO | claimed |