Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 5/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 8/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 5/20 | 0.43 |
| ▸ | TEK | Q02763 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 3/20 | 0.42 |
| ▸ | LYN | P07948 | 3/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | FLT4 | P35916 | 3/20 | 0.42 |
| ▸ | BLK | P51451 | 3/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4262663 | 0.91 | RIPK2 (0.58) | RIPK2RIPK1KDRSRCCSNK1E | |
| SCHEMBL4260556 | 0.91 | RIPK2 (0.53) | RIPK2KDRSRCPDGFRBEPHA3 | |
| SCHEMBL4260583 | 0.88 | KDR (0.55) | RIPK2RIPK1KDRSRCPDGFRB | |
| SCHEMBL6614602 | 0.87 | RIPK2 (0.50) | RIPK2RIPK1KDRSRCPDGFRB | |
| SCHEMBL4258858 | 0.82 | RET (0.55) | RIPK1KDRSRCPDGFRBFLT1 | |
| SCHEMBL4257250 | 0.81 | KDR (0.50) | KDRSRCPDGFRBEPHA3EPHB4 | |
| SCHEMBL4257211 | 0.81 | RIPK1 (0.53) | RIPK2RIPK1KDRPDGFRBCSNK1E | |
| SCHEMBL6602055 | 0.81 | MEN1 (0.53) | RIPK1KDRSRCPDGFRBFLT1 | |
| SCHEMBL4257460 | 0.81 | RIPK2 (0.62) | RIPK2KDRSRCPDGFRBLCK | |
| SCHEMBL4255774 | 0.80 | RIPK2 (0.59) | RIPK2KDRSRCPDGFRBFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436265-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-12-15 | — | — | EP | claimed |
| EP-1436265-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2004-07-14 | — | — | EP | claimed |
| WO-2003072541-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-04 | — | — | WO | claimed |
| EP-1417190-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgen Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003009850-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC. (US) | 2003-02-06 | — | — | WO | disclosed |