Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.57 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 7/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5404931 | 0.89 | ROCK2 (0.54) | MAPK14ROCK2ROCK1MAOBMAOA | |
| SCHEMBL5417028 | 0.84 | ROCK2 (0.52) | MAPK14ROCK2ROCK1MAOBMAOA | |
| SCHEMBL5417444 | 0.84 | TAS1R3 (0.57) | TAS1R3TAS1R1MAPK14ROCK2ROCK1 | |
| SCHEMBL5409232 | 0.84 | ROCK2 (0.52) | MAPK14ROCK2ROCK1MAOBMAOA | |
| SCHEMBL5409227 | 0.84 | ROCK2 (0.52) | MAPK14ROCK2ROCK1MAOBMAOA | |
| SCHEMBL5405635 | 0.83 | TDO2 (0.57) | MAPK14ROCK2ROCK1MAOBNPC1 | |
| SCHEMBL5409687 | 0.83 | TDO2 (0.57) | MAPK14ROCK2ROCK1MAOBNPC1 | |
| SCHEMBL5259997 | 0.82 | ROCK2 (0.46) | MAPK14ROCK2ROCK1MAOBPOLB | |
| SCHEMBL5407417 | 0.80 | ROCK2 (0.53) | MAPK14ROCK2ROCK1CNR2MAOB | |
| SCHEMBL5407422 | 0.80 | ROCK2 (0.53) | MAPK14ROCK2ROCK1CNR2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |