⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600024 | 0.85 | — | — | |
| SCHEMBL6003621 | 0.65 | NQO1 (0.30) | — | |
| SCHEMBL6003760 | 0.65 | REV1 (0.30) | — | |
| SCHEMBL10414868 | 0.64 | NQO1 (0.50) | — | |
| SCHEMBL6003429 | 0.62 | AXL (0.30) | — | |
| SCHEMBL5508757 | 0.62 | — | — | |
| SCHEMBL14166403 | 0.60 | NQO1 (0.39) | — | |
| SCHEMBL20449075 | 0.58 | LMNA (0.36) | — | |
| SCHEMBL21051215 | 0.58 | — | — | |
| SCHEMBL2889730 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1396491-A2 | 2-substituted 4,5-diaryl-imidazoles and their use as p38 MAP kinase inhibitors | Novartis AG (CH) | 2004-03-10 | — | — | EP | disclosed |
| US-6300347-B1 | FOR THERAPY OF TUMOR NECROSIS FACTOR AND INTERLEUKIN-1 MEDIATED DISEASES SUCH AS RHEUMATOID ARTHRITIS AND DISEASES OF BONE METABOLISM, E.G. OSTEOPOROSIS | NOVARTIS AG (CH) | 2001-10-09 | — | — | US | disclosed |