SCHEMBL6602578

SCHEMBL6602578

COc1ccc(C2CC(O)=CC(=O)O2)cc1

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP1B1 Q16678 1/20 0.52
MAOB P27338 9/20 0.51
CYP19A1 P11511 7/20 0.51
MAPT P10636 2/20 0.51
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51
CYP3A4 P08684 1/20 0.51
ALDH1A1 P00352 1/20 0.47
ADORA3 P0DMS8 1/20 0.47
ATM Q13315 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
TAS2R31 P59538 1/20 0.47
ABCG2 Q9UNQ0 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6607888 0.83 MAOB (0.48) MAOBALDH1A1
SCHEMBL31607964 0.82 CYP19A1 (0.50) CYP1A1CYP1A2CYP1B1MAOBCYP19A1
SCHEMBL6602817 0.80 ALOX12 (0.53) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
SCHEMBL4206063 0.79 MAOB (0.49) CYP1A1CYP1A2CYP1B1MAOBCYP19A1
SCHEMBL6603263 0.79 SLC6A2 (0.39) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
SCHEMBL6605596 0.79 CYP19A1 (0.35) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
SCHEMBL6604755 0.77 LMNA (0.48) CYP1A2MAOB
SCHEMBL6609372 0.77 ADORA3 (0.42) CYP1A1CYP1A2CYP1B1MAOBCYP19A1
SCHEMBL6607571 0.76 CYP19A1 (0.45) CYP1A1CYP1A2CYP1B1CYP19A1MAPT
SCHEMBL12019823 0.75 MAOB (0.57) CYP1A1CYP1A2CYP1B1MAOBCYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1142887-B1 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents PARKE DAVIS & CO (US) 2004-04-07 EP disclosed
EP-0729463-B1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2002-05-22 EP disclosed
EP-1142887-A1 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents PARKE, DAVIS & COMPANY (US) 2001-10-10 EP disclosed
US-5936128-A BENZENETHIOL COMPOUNDS AS INTERMEDIATES; BACTERICIDES, VIRICIDES; HIV WARNER-LAMBERT COMPANY (US) 1999-08-10 US disclosed
US-5840751-A ADMINISTERING IN THE TREATMENT OF INFECTION OR DISEASE CAUSED BY A RETROVIRUS WARNER-LAMBERT COMPANY (US) 1998-11-24 US disclosed
US-5789440-A 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents WARNER-LAMBERT COMPANY (US) 1998-08-04 US disclosed
EP-0729464-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729463-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014012-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014011-A2 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed