Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.73 |
| ▸ | CTSV | O60911 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602938 | 1.00 | CTSK (0.73) | CTSKCTSVCTSBCTSSPKM | |
| SCHEMBL6605883 | 0.86 | CTSK (0.71) | CTSKMAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL6605878 | 0.86 | CTSK (0.71) | CTSKMAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL5636660 | 0.82 | CTSK (0.63) | CTSKCTSVCTSBCTSSPKM | |
| SCHEMBL5636688 | 0.82 | CTSK (0.63) | CTSKCTSVCTSBCTSSPKM | |
| SCHEMBL14943570 | 0.81 | CTSK (0.60) | CTSKPKMKMT2ATRPV1MAPT | |
| SCHEMBL6601981 | 0.79 | PKM (0.56) | CTSKPKMKMT2ATRPV1FAAH | |
| SCHEMBL16317048 | 0.78 | CTSK (0.57) | CTSKCTSVCTSBCTSSPKM | |
| SCHEMBL12330547 | 0.77 | KMT2A (0.56) | CTSKPKMKMT2ATRPV1MAPT | |
| SCHEMBL13101028 | 0.76 | PKM (0.61) | CTSKPKMKMT2AMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411933-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SmithKline Beecham Corporation (US) | 2004-04-28 | — | — | EP | claimed |
| WO-2003013518-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-02-20 | — | — | WO | claimed |
| EP-1411933-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SmithKline Beecham Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003013518-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |