Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605883 | 1.00 | CTSK (0.71) | CTSKLMNAMAPTMAPK1L3MBTL1 | |
| SCHEMBL6602953 | 0.86 | CTSK (0.73) | CTSKLMNAMAPTL3MBTL1HTT | |
| SCHEMBL6602938 | 0.86 | CTSK (0.73) | CTSKLMNAMAPTL3MBTL1HTT | |
| SCHEMBL14943763 | 0.79 | LMNA (0.58) | CTSKLMNAMAPTMAPK1L3MBTL1 | |
| SCHEMBL12518046 | 0.77 | CTSK (0.54) | CTSKL3MBTL1ALDH1A1 | |
| SCHEMBL12401725 | 0.76 | RAB9A (0.57) | CTSKLMNAMAPTMAPK1L3MBTL1 | |
| SCHEMBL23835832 | 0.73 | HTT (0.59) | CTSKLMNAMAPTMAPK1L3MBTL1 | |
| SCHEMBL10352586 | 0.72 | LMNA (0.63) | CTSKLMNAMAPTMAPK1RAB9A | |
| SCHEMBL4317649 | 0.72 | CTSK (0.71) | CTSK | |
| SCHEMBL6604125 | 0.72 | CTSK (0.71) | CTSKRAB9AHTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411933-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SmithKline Beecham Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003013518-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |