Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607689 | 0.88 | ALDH1A1 (0.37) | ALDH1A1KDM4EHPGDPOLBMAPK1 | |
| SCHEMBL6604031 | 0.86 | SMN1; SMN2 (0.46) | ALDH1A1KDM4EHPGDMAPK1GAA | |
| SCHEMBL6604038 | 0.85 | PPARA (0.36) | ALDH1A1KDM4EHPGDPOLBMAPK1 | |
| SCHEMBL5167234 | 0.84 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDPOLBMAPK1 | |
| SCHEMBL6603196 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDPOLBMAPK1 | |
| SCHEMBL6603210 | 0.82 | PDE10A (0.42) | ALDH1A1KDM4EHPGDMAPK1STAT3 | |
| SCHEMBL6602795 | 0.76 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDPOLBMAPK1 | |
| SCHEMBL6605643 | 0.76 | SMN1; SMN2 (0.49) | ALDH1A1KDM4EHPGDPOLBGAA | |
| SCHEMBL29138976 | 0.75 | KDM4E (0.47) | ALDH1A1KDM4EHPGDPOLBTDP1 | |
| SCHEMBL30631722 | 0.75 | KDM4E (0.47) | ALDH1A1KDM4EHPGDPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119355-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-01-08 | — | — | EP | disclosed |
| US-6500818-B1 | Naphthalenecarboxamides as tachykinin receptor antagonists | ASTRAZENECA AB (SE) | 2002-12-31 | — | — | US | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| EP-1119355-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020003-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |