Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603036 | 0.88 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDPOLBTDP1 | |
| SCHEMBL4657378 | 0.85 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDPOLBTDP1 | |
| SCHEMBL6604031 | 0.85 | SMN1; SMN2 (0.46) | ALDH1A1KDM4EHPGDTDP1MAPK1 | |
| SCHEMBL6606804 | 0.75 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDTDP1SMN1; SMN2 | |
| SCHEMBL6605643 | 0.75 | SMN1; SMN2 (0.49) | ALDH1A1KDM4EHPGDPOLBTDP1 | |
| SCHEMBL5167234 | 0.75 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDPOLBMAPK1 | |
| SCHEMBL6604038 | 0.73 | PPARA (0.36) | ALDH1A1KDM4EHPGDPOLBTDP1 | |
| SCHEMBL31171419 | 0.73 | KDM4E (0.61) | ALDH1A1KDM4EPOLBTDP1MAPK1 | |
| SCHEMBL4958710 | 0.73 | KDM4E (0.61) | ALDH1A1KDM4EPOLBTDP1MAPK1 | |
| SCHEMBL6603210 | 0.72 | PDE10A (0.42) | ALDH1A1KDM4EHPGDTDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |