Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605643 | 0.88 | SMN1; SMN2 (0.49) | SMN1; SMN2TDP1ALDH1A1HTTNPSR1 | |
| SCHEMBL6606804 | 0.86 | ALDH1A1 (0.45) | SMN1; SMN2TDP1ALDH1A1HTTNPSR1 | |
| SCHEMBL6603036 | 0.86 | ALDH1A1 (0.40) | SMN1; SMN2TDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL6607689 | 0.85 | ALDH1A1 (0.37) | SMN1; SMN2TDP1ALDH1A1KDM4EMAPT | |
| SCHEMBL6604432 | 0.83 | ALOX15 (0.43) | SMN1; SMN2TDP1ALDH1A1HTTNPSR1 | |
| SCHEMBL6604264 | 0.78 | ALOX15 (0.41) | SMN1; SMN2TDP1ALDH1A1HTTNPSR1 | |
| SCHEMBL3562795 | 0.74 | CA12 (0.50) | SMN1; SMN2ALDH1A1NPSR1ADORA3KDM4E | |
| SCHEMBL6264079 | 0.73 | MEN1 (0.49) | SMN1; SMN2ALDH1A1NPSR1L3MBTL1KDM4E | |
| SCHEMBL6603210 | 0.73 | PDE10A (0.42) | SMN1; SMN2TDP1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL5167234 | 0.73 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1HTTKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |