Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL670409 | 0.92 | HPGD (0.57) | HPGDNPC1RAB9AALDH1A1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL30440814 | 0.77 | PYGL (0.47) | HPGDNPC1RAB9AALDH1A1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL17238937 | 0.77 | PYGL (0.47) | HPGDNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL658861 | 0.76 | ALDH1A1 (0.47) | HPGDNPC1RAB9AALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL660384 | 0.76 | CHIT1 (0.46) | HPGDNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL659201 | 0.75 | ALDH1A1 (0.46) | HPGDNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL659467 | 0.72 | ALDH1A1 (0.51) | ALDH1A1MAPTTSHRLMNA | |
| SCHEMBL5193854 | 0.71 | KDM4E (0.51) | HPGDNPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL28242416 | 0.69 | CA12 (0.54) | HPGDNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL17414148 | 0.69 | LPAR1 (0.59) | HPGDALDH1A1SMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012022707-A1 | SUBSTITUTED HETEROARYL SPIROPYRROLIDINE MDM2 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-02-23 | — | — | WO | disclosed |
| US-20120046306-A1 | Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists | BARTKOVITZ DAVID JOSEPH (US) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046306-A1 | Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists | MDM2, TP53, RB1 | HPGD 1707/4885NPC1 3887/4885RAB9A 2171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.