SCHEMBL6603312

SCHEMBL6603312

COc1nc2cc([N+](=O)[O-])c(F)cc2nc1C(N)=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNMA1 Q12791 2/20 0.38
POLB P06746 4/20 0.36
LMNA P02545 2/20 0.36
GALR2 O43603 1/20 0.36
TDP1 Q9NUW8 3/20 0.36
HCRTR1 O43613 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C19 P33261 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
KDM4E B2RXH2 1/20 0.34
CTDSP1 Q9GZU7 1/20 0.34
MAPT P10636 2/20 0.34
ESPL1 Q14674 1/20 0.33
MEN1 O00255 1/20 0.33
RAB9A P51151 1/20 0.33
KMT2A Q03164 1/20 0.33
CASP3 P42574 1/20 0.33
SENP8 Q96LD8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5722679 0.85 POLB (0.45) POLBLMNAGALR2TDP1KDM4E
SCHEMBL6602596 0.83 ALDH1A1 (0.41) POLBLMNAGALR2CYP1A2CYP2C19
SCHEMBL6377194 0.73 ALDH1A1 (0.44) POLBLMNAGALR2CYP1A2CYP2C19
SCHEMBL6380676 0.73 ALDH1A1 (0.44) POLBLMNAGALR2CYP1A2CYP2C19
SCHEMBL9703955 0.73 HRH4 (0.43) POLBLMNASMN1; SMN2KDM4ERAB9A
SCHEMBL6603496 0.72 GRIN2D (0.43) LMNACYP1A2MAPT
SCHEMBL15514790 0.71 POLB (0.43) KCNMA1POLBLMNATDP1CYP1A2
SCHEMBL6607045 0.70 ALDH1A1 (0.43) POLBLMNAGALR2SMN1; SMN2L3MBTL1
SCHEMBL15486753 0.70 POLB (0.45) POLBLMNATDP1L3MBTL1KDM4E
SCHEMBL5189809 0.70 HDAC6 (0.50) SMN1; SMN2L3MBTL1KDM4EMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1020453-B1 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERIVATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH KYORIN SEIYAKU KK (JP) 2004-05-19 EP disclosed
US-6348461-B1 CENTRAL NERVOUS SYSTEM ANTAGONIST WITH HETEROCYCLIC SUBSTITUENTS KYORIN PHARMACEUTICAL CO., LTD. (JP) 2002-02-19 US disclosed
EP-1020453-A1 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERI VATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH KYORIN PHARMACEUTICAL CO., LTD. (JP) 2000-07-19 EP disclosed