Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | GALR2 | O43603 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | PGK1 | P00558 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603312 | 0.85 | KCNMA1 (0.38) | POLBGALR2LMNATDP1ATM | |
| SCHEMBL6602596 | 0.81 | ALDH1A1 (0.41) | POLBGALR2LMNAALDH1A1MAPT | |
| SCHEMBL5722727 | 0.77 | POLB (0.44) | POLBGALR2LMNATDP1ATM | |
| SCHEMBL5722594 | 0.77 | LMNA (0.37) | POLBGALR2LMNATDP1ATM | |
| SCHEMBL30905617 | 0.76 | GRIA1 (0.68) | POLBGALR2LMNATDP1ALDH1A1 | |
| SCHEMBL23620108 | 0.76 | ALDH1A1 (0.40) | POLBGALR2LMNATDP1ATM | |
| SCHEMBL29829625 | 0.76 | ALDH1A1 (0.40) | POLBGALR2LMNATDP1ATM | |
| SCHEMBL13729984 | 0.75 | ALDH1A1 (0.42) | TDP1ATMALDH1A1HIF1AHTT | |
| SCHEMBL29830193 | 0.75 | ALDH1A1 (0.42) | TDP1ATMALDH1A1HIF1AHTT | |
| SCHEMBL7960036 | 0.74 | ALDH1A1 (0.40) | POLBGALR2LMNATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097927-B1 | CYANOIMINOQUINOXALINE DERIVATIVES | SHIONOGI & CO (JP) | 2006-07-19 | — | — | EP | disclosed |
| US-6525054-B1 | Antagonistic effects on glutamate receptors of central neurons, in particular, NMDA receptors and AMPA receptors; diseases due to hyperexcitation of glutamate receptors | SHIONOGI & CO., LTD. (JP) | 2003-02-25 | — | — | US | disclosed |
| CN-1304404-A | Cyanoiminoquinoxaline derivatives | SHIONOGI & CO (JP) | 2001-07-18 | — | — | CN | disclosed |
| EP-1097927-A1 | CYANOIMINOQUINOXALINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2001-05-09 | — | — | EP | disclosed |