Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.31 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5360787 | 0.68 | MAPT (0.36) | ALDH1A1 | |
| SCHEMBL10733624 | 0.62 | CALM1 (0.50) | CALM1MAOAMAOBALDH1A1LTB4R | |
| SCHEMBL9569413 | 0.61 | CALM1 (0.38) | CALM1EPHX2MAOAMAOBALDH1A1 | |
| SCHEMBL2339223 | 0.60 | CALM1 (0.42) | CALM1MAOAMAOBALDH1A1LTB4R | |
| Diphenylmethane SCHEMBL1303 | 0.60 | CALM1 (1.00) | CALM1MAOBALDH1A1PLA2G10PLA2G2A | |
| Diphenylmethane SCHEMBL14763944 | 0.60 | CALM1 (1.00) | CALM1MAOBALDH1A1PLA2G10PLA2G2A | |
| Diphenylmethane SCHEMBL28172316 | 0.60 | CALM1 (1.00) | CALM1MAOBALDH1A1PLA2G10PLA2G2A | |
| Diphenylmethane SCHEMBL4361124 | 0.60 | CALM1 (1.00) | CALM1MAOBALDH1A1PLA2G10PLA2G2A | |
| Diphenylmethane SCHEMBL3792579 | 0.60 | CALM1 (1.00) | CALM1MAOBALDH1A1PLA2G10PLA2G2A | |
| Diphenylmethane SCHEMBL28138127 | 0.59 | CALM1 (0.80) | CALM1EPHX2ALDH1A1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1308446-B1 | 5-(alkylidene-cycloalkyl)- and 5-(alkylidene-heterocyclyl)-pyrazoles | PFIZER PROD INC (US) | 2004-12-08 | — | — | EP | disclosed |