Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.45 |
| ▸ | PDE4A | P27815 | 9/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600797 | 0.93 | ALDH1A1 (0.48) | ALDH1A1LMNAPKMNPSR1CFTR | |
| SCHEMBL6608236 | 0.92 | PDE4D (0.46) | PDE5APDE1APDE1BPDE1CPDE4D | |
| SCHEMBL6604689 | 0.89 | ALDH1A1 (0.45) | ALDH1A1LMNAPKMNPSR1CFTR | |
| SCHEMBL6600966 | 0.89 | PDE4A (0.48) | PDE5APDE1APDE1BPDE1CPDE4D | |
| SCHEMBL6601233 | 0.88 | PDE5A (0.46) | PDE5APDE1APDE1BPDE1CPDE4D | |
| SCHEMBL6602086 | 0.88 | PDE5A (0.49) | PDE5APDE1APDE1BPDE1CPDE4D | |
| SCHEMBL6601657 | 0.87 | RAB9A (0.47) | PDE5APDE1APDE1BPDE1CPDE4D | |
| SCHEMBL6581707 | 0.87 | PDE4D (0.51) | PDE5APDE1APDE1BPDE1CPDE4D | |
| SCHEMBL6602063 | 0.86 | PDE4B (0.52) | PDE5APDE1APDE1BPDE1CPDE4D | |
| SCHEMBL6607012 | 0.86 | PDE4B (0.52) | PDE5APDE1APDE1BPDE1CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |
| EP-0922036-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GmbH (DE) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998006704-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |