Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599683 | 0.93 | HTR2A (0.71) | KMT2AMEN1SMN1; SMN2MAPTHTR1A | |
| Hydrochloric Acid SCHEMBL11602872 | 0.91 | HTR2A (0.70) | KMT2AMEN1SMN1; SMN2MAPTHTR1A | |
| SCHEMBL8265592 | 0.88 | MEN1 (0.62) | KMT2AMEN1SMN1; SMN2MAPTNPC1 | |
| Oxalic Acid SCHEMBL29489386 | 0.85 | KMT2A (0.66) | KMT2AMEN1SMN1; SMN2MAPTHTR1A | |
| SCHEMBL28413707 | 0.84 | HRH3 (0.63) | KMT2AMEN1HTR1ADRD2HTR2A | |
| SCHEMBL8263255 | 0.81 | HTR2A (0.65) | KMT2AMEN1HTR1ADRD2HTR2A | |
| SCHEMBL7015692 | 0.81 | HRH3 (0.67) | KMT2AMEN1MAPTHTR1ADRD2 | |
| SCHEMBL6394942 | 0.81 | MEN1 (0.76) | KMT2AMEN1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL734585 | 0.81 | MEN1 (1.00) | KMT2AMEN1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL7675374 | 0.79 | MEN1 (0.66) | KMT2AMEN1SMN1; SMN2MAPTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379239-A2 | N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002078693-A2 | N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2002-10-10 | — | — | WO | disclosed |