Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 1.00 |
| ▸ | GOT1 | P17174 | 8/20 | 0.81 |
| ▸ | MAPT | P10636 | 8/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.79 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23925545 | 0.85 | MAPT (0.76) | MEN1KMT2AGOT1MAPTSMN1; SMN2 | |
| SCHEMBL26430630 | 0.85 | MAPT (0.76) | MEN1KMT2AGOT1MAPTSMN1; SMN2 | |
| SCHEMBL23925476 | 0.85 | MAPT (0.76) | MEN1KMT2AGOT1MAPTSMN1; SMN2 | |
| SCHEMBL6394942 | 0.84 | MEN1 (0.76) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL23925495 | 0.84 | GOT1 (1.00) | MEN1KMT2AGOT1MAPTSMN1; SMN2 | |
| SCHEMBL11280301 | 0.84 | MEN1 (0.71) | MEN1KMT2AGOT1MAPTSMN1; SMN2 | |
| SCHEMBL1520004 | 0.84 | MEN1 (0.81) | MEN1KMT2AGOT1MAPTSMN1; SMN2 | |
| SCHEMBL13719678 | 0.84 | MEN1 (0.72) | MEN1KMT2AGOT1MAPTSMN1; SMN2 | |
| SCHEMBL735830 | 0.84 | KMT2A (0.72) | MEN1KMT2AGOT1MAPTSMN1; SMN2 | |
| SCHEMBL174362 | 0.82 | MEN1 (0.72) | MEN1KMT2AGOT1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101516844-B | 4-heteroaryl substituted 1-aminocyclohexane-1-and cyclohexene-1-derivatives having activity on opioid receptor systems | GRUENENTHAL GMBH | 2013-12-11 | — | — | CN | disclosed |
| US-8138187-B2 | Substituted heteroaryl derivatives | GRUENENTHAL GMBH (DE) | 2012-03-20 | — | — | US | disclosed |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
| CN-101516844-A | 4-heteroaryl substituted 1-aminocyclohexane-1-and cyclohexene-1-derivatives having activity on opioid receptor systems | GRUENENTHAL GMBH (DE) | 2009-08-26 | — | — | CN | disclosed |
| US-7576245-B2 | Fluorous tagging and scavenging reactants and methods of synthesis and use thereof | FLUOROUS TECHNOLOGIES INCORPORATED (US) | 2009-08-18 | — | — | US | disclosed |
| US-7576245-B2 | Fluorous tagging and scavenging reactants and methods of synthesis and use thereof | FLUOROUS TECHNOLOGIES INCORPORATED (US) | 2009-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | MEN1 2253/4885KMT2A 2453/4885GOT1 366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.