Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 2/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604281 | 0.87 | KDM4E (0.47) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL6229441 | 0.87 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDNPSR1NCEH1 | |
| SCHEMBL6606505 | 0.86 | MAPT (0.38) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL6606670 | 0.86 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDNPSR1NCEH1 | |
| SCHEMBL6605993 | 0.82 | LMNA (0.45) | ALDH1A1KDM4EHPGDNPSR1NCEH1 | |
| SCHEMBL6603195 | 0.82 | POLB (0.42) | ALDH1A1KDM4EHPGDNPSR1NCEH1 | |
| SCHEMBL4676934 | 0.80 | MEN1 (0.45) | ALDH1A1KDM4EHPGDNPSR1NCEH1 | |
| SCHEMBL10699646 | 0.80 | NCEH1 (0.44) | ALDH1A1KDM4EHPGDNPSR1NCEH1 | |
| SCHEMBL6510652 | 0.80 | NCEH1 (0.44) | ALDH1A1KDM4EHPGDNPSR1NCEH1 | |
| SCHEMBL6603719 | 0.79 | NCEH1 (0.40) | ALDH1A1KDM4EHPGDNPSR1NCEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |