Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 3/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606632 | 0.87 | MEN1 (0.44) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL6603583 | 0.86 | ALDH1A1 (0.42) | ALDH1A1HPGDKDM4EL3MBTL1NPSR1 | |
| SCHEMBL6229441 | 0.83 | ALDH1A1 (0.52) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL4673550 | 0.81 | NCEH1 (0.39) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL10699646 | 0.79 | NCEH1 (0.44) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL6605993 | 0.79 | LMNA (0.45) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL4676934 | 0.76 | MEN1 (0.45) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL6510652 | 0.76 | NCEH1 (0.44) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL6603195 | 0.76 | POLB (0.42) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL6508770 | 0.75 | POLB (0.41) | ALDH1A1HPGDKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |