Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 7/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601098 | 0.93 | ADRA2A (0.44) | ADRA2AMCHR1KDM4ETDP1CCR5 | |
| SCHEMBL1427490 | 0.87 | KDM4E (0.59) | ADRA2AMCHR1KDM4ETDP1CCR5 | |
| SCHEMBL24192354 | 0.85 | ALDH1A1 (0.51) | ADRA2AMCHR1KDM4ETDP1CCR5 | |
| SCHEMBL15094644 | 0.83 | ADRA2A (0.47) | ADRA2AMCHR1KDM4ETDP1CCR5 | |
| SCHEMBL28171356 | 0.82 | ADRA2A (0.46) | ADRA2AMCHR1KDM4ETDP1CCR5 | |
| SCHEMBL15094084 | 0.81 | MGLL (0.49) | ADRA2AMCHR1KDM4EEPHX2MGLL | |
| SCHEMBL30207457 | 0.76 | MGLL (0.52) | ADRA2AMCHR1KDM4EEPHX2MGLL | |
| SCHEMBL15100926 | 0.76 | MGLL (0.52) | ADRA2AMCHR1KDM4EEPHX2MGLL | |
| SCHEMBL27611215 | 0.76 | MCHR1 (0.54) | ADRA2AMCHR1KDM4EEPHX2 | |
| SCHEMBL29555215 | 0.74 | EPHX2 (0.41) | ADRA2AMCHR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1582281-A | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO LTD (JP) | 2005-02-16 | — | — | CN | disclosed |
| EP-1432693-A2 | MCH RECEPTOR ANTAGONISTS | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028641-A2 | MCH RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2003-04-10 | — | — | WO | disclosed |