Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 10/20 | 0.46 |
| ▸ | HTR1D | P28221 | 6/20 | 0.44 |
| ▸ | HTR1B | P28222 | 6/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603712 | 1.00 | GHSR (0.46) | GHSRHTR1DHTR1BLCKHTR1A | |
| SCHEMBL6604346 | 0.92 | HTR1D (0.54) | GHSRHTR1DHTR1BLCKHTR1A | |
| SCHEMBL6604349 | 0.92 | HTR1D (0.54) | GHSRHTR1DHTR1BLCKHTR1A | |
| SCHEMBL6605304 | 0.79 | HTR1B (0.69) | GHSRHTR1DHTR1BHTR1A | |
| SCHEMBL6605279 | 0.79 | HTR1B (0.69) | GHSRHTR1DHTR1BHTR1A | |
| SCHEMBL6606338 | 0.74 | HTR1B (0.67) | GHSRHTR1DHTR1BHTR1A | |
| SCHEMBL6606340 | 0.74 | HTR1B (0.67) | GHSRHTR1DHTR1BHTR1A | |
| SCHEMBL6604742 | 0.72 | HTR1B (0.66) | GHSRHTR1DHTR1BHTR1A | |
| SCHEMBL6604746 | 0.72 | HTR1B (0.66) | GHSRHTR1DHTR1BHTR1A | |
| SCHEMBL6604750 | 0.72 | HTR1B (0.81) | GHSRHTR1DHTR1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216239-B1 | PIPERAZINE DERIVATIVES AS 5-HT1B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-02-11 | — | — | EP | claimed |
| EP-1216239-B1 | PIPERAZINE DERIVATIVES AS 5-HT1B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-02-11 | — | — | EP | disclosed |