Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MITF | O75030 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604698 | 0.90 | KMT2A (0.56) | MEN1KMT2APAX8POLBMAPT | |
| SCHEMBL6604033 | 0.90 | KMT2A (0.55) | MEN1KMT2APAX8POLBMAPT | |
| SCHEMBL6604028 | 0.90 | MCHR1 (0.57) | MEN1KMT2APAX8POLBMAPT | |
| SCHEMBL6928643 | 0.81 | MCHR1 (0.65) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL6602432 | 0.79 | TSHR (0.63) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL25005573 | 0.76 | STING1 (0.62) | MEN1KMT2APAX8POLBMAPT | |
| SCHEMBL6927364 | 0.75 | MCHR1 (0.70) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL6427130 | 0.74 | MEN1 (1.00) | MEN1KMT2APAX8POLBMAPT | |
| SCHEMBL6427707 | 0.73 | LMNA (0.64) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL6427480 | 0.73 | MEN1 (0.75) | MEN1KMT2APAX8POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6399656-B1 | USING A BENZOPYRAN-3-CARBOXAMIDE COMPOUND | SMITHKLINE BEECHAM CORPORATION | 2002-06-04 | — | — | US | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |