Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.54 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.54 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.54 |
| ▸ | CHRNB3 | Q05901 | 4/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441671 | 0.87 | CHRNB2 (0.59) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7441682 | 0.87 | CHRNB2 (0.59) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL4129880 | 0.83 | CHRNB2 (0.54) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7488929 | 0.82 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7488933 | 0.82 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7488938 | 0.82 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7488922 | 0.82 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL14174981 | 0.78 | CHRNB2 (0.69) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL9242858 | 0.77 | CHRNB4 (0.70) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL9243572 | 0.77 | CHRNB4 (0.70) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458679-A2 | PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003053923-A2 | PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-07-03 | — | — | WO | disclosed |