Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.59 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.59 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441682 | 1.00 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL4129880 | 0.96 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL4128207 | 0.87 | HRH3 (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL6603836 | 0.87 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL4118891 | 0.85 | HRH3 (0.48) | — | |
| SCHEMBL14174981 | 0.82 | CHRNB2 (0.69) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL7488933 | 0.82 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL7488938 | 0.82 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL7488922 | 0.82 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL7488929 | 0.82 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912567-B1 | CARBOLINE DERIVATIVES | ICOS CORP (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6306870-B1 | PHOSPHODIESTERASE ENZYME INHIBITORS, CARDIOVASCULAR DISORDERS AND SEXUAL DISORDERS | ICOS CORPORATION | 2001-10-23 | — | — | US | disclosed |
| CN-1067071-C | Carboline derivatives | ICOS CORP (US) | 2001-06-13 | — | — | CN | disclosed |
| US-6117881-A | POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE | ICOS CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
| US-6043252-A | A POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE (CGMP-SPECIFIC PDE); TREATING CARDIOVASCULAR DISORDERS AND ERECTILE DYSFUNCTION | ICOS CORPORATION (US) | 2000-03-28 | — | — | US | disclosed |
| CN-1218471-A | Carboline derivatives | ICOS CORP (US) | 1999-06-02 | — | — | CN | disclosed |
| EP-0912567-A1 | CARBOLINE DERIVATIVES | ICOS CORPORATION (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997043287-A1 | CARBOLINE DERIVATIVES | ICOS CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |