Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.55 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.55 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.55 |
| ▸ | CHRNB3 | Q05901 | 4/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.52 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488933 | 1.00 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7488929 | 1.00 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7488922 | 1.00 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6603836 | 0.82 | CHRNB2 (0.54) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7441682 | 0.82 | CHRNB2 (0.59) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7441671 | 0.82 | CHRNB2 (0.59) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL26729857 | 0.81 | CHRNB2 (0.62) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| Fumaric Acid SCHEMBL1796369 | 0.79 | CHRNB4 (0.54) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| Fumaric Acid SCHEMBL1796367 | 0.79 | CHRNB4 (0.54) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| Fumaric Acid SCHEMBL1796371 | 0.79 | CHRNB4 (0.54) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912567-B1 | CARBOLINE DERIVATIVES | ICOS CORP (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6117881-A | POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE | ICOS CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
| US-6043252-A | A POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE (CGMP-SPECIFIC PDE); TREATING CARDIOVASCULAR DISORDERS AND ERECTILE DYSFUNCTION | ICOS CORPORATION (US) | 2000-03-28 | — | — | US | disclosed |