Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 6/20 | 0.32 |
| ▸ | RARB | P10826 | 6/20 | 0.32 |
| ▸ | RARG | P13631 | 6/20 | 0.32 |
| ▸ | RXRA | P19793 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8609967 | 0.84 | SKP2 (0.39) | ALDH1A1CYP3A4 | |
| SCHEMBL6665874 | 0.84 | SKP2 (0.39) | ALDH1A1CYP3A4 | |
| SCHEMBL6664705 | 0.83 | SKP2 (0.41) | RARARARBRARGRXRAHPGD | |
| SCHEMBL3263389 | 0.81 | ALDH1A1 (0.37) | RARARARBRARGRXRAALDH1A1 | |
| SCHEMBL6668119 | 0.78 | CYP26A1 (0.35) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL8608638 | 0.77 | SKP2 (0.37) | ALDH1A1CYP3A4 | |
| SCHEMBL6670538 | 0.75 | RARA (0.37) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL6610206 | 0.75 | CYP26A1 (0.34) | RARARARBRARGRXRAHDAC1 | |
| SCHEMBL7143189 | 0.68 | CYP26B1 (0.47) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL19741573 | 0.68 | HDAC1 (0.40) | HDAC1HDAC4USP2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442032-A1 | HETEROCYCLIC RETINOID COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003037882-A1 | HETEROCYCLIC RETINOID COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-08 | — | — | WO | disclosed |