Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602109 | 0.95 | RAB9A (0.53) | RAB9ASMN1; SMN2NPC1HPGDMAPT | |
| SCHEMBL6602654 | 0.92 | RAB9A (0.47) | RAB9ASMN1; SMN2NPC1HPGDMAPT | |
| SCHEMBL6602816 | 0.92 | NPC1 (0.48) | RAB9ASMN1; SMN2NPC1MAPTPKM | |
| SCHEMBL146882 | 0.91 | MAPK1 (0.46) | RAB9ASMN1; SMN2NPC1MAPTPKM | |
| SCHEMBL6603283 | 0.90 | ALDH1A1 (0.43) | RAB9ASMN1; SMN2NPC1HPGDMAPT | |
| Hydrochloric Acid SCHEMBL7652761 | 0.90 | MAPK1 (0.45) | RAB9ASMN1; SMN2NPC1MAPTPKM | |
| SCHEMBL6600753 | 0.89 | SMN1; SMN2 (0.44) | RAB9ASMN1; SMN2NPC1PKMLMNA | |
| SCHEMBL6601657 | 0.89 | RAB9A (0.47) | RAB9ASMN1; SMN2NPC1HPGDPKM | |
| SCHEMBL6601223 | 0.88 | ALDH1A1 (0.44) | RAB9ASMN1; SMN2NPC1MAPTPKM | |
| SCHEMBL6582371 | 0.88 | NPC1 (0.49) | RAB9ASMN1; SMN2NPC1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| EP-1143944-A3 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2002-09-11 | — | — | EP | disclosed |
| EP-1143944-A2 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000059484-A2 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2000-10-12 | — | — | WO | disclosed |
| EP-0922036-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GmbH (DE) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998006704-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |