Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CCL2 | P13500 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 2/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135571 | 0.80 | EDNRA (0.33) | EDNRAATMMEN1KMT2AALDH1A1 | |
| SCHEMBL10900635 | 0.80 | EDNRA (0.34) | EDNRAATMMEN1KMT2AEDNRB | |
| SCHEMBL9233000 | 0.79 | BRD4 (0.35) | BRD4CCL2ATMMEN1KMT2A | |
| SCHEMBL1931383 | 0.78 | ATM (0.32) | EDNRAATM | |
| SCHEMBL28725904 | 0.77 | BRD4 (0.36) | BRD4CCL2MEN1KMT2ASIGMAR1 | |
| SCHEMBL28675069 | 0.73 | BRD4 (0.35) | BRD4CCL2EDNRAATMMEN1 | |
| SCHEMBL27942046 | 0.73 | ALDH1A1 (0.36) | BRD4CCL2MEN1KMT2ASIGMAR1 | |
| SCHEMBL9649130 | 0.70 | HSD11B1 (0.35) | BRD4CCL2ATMKMT2ASIGMAR1 | |
| SCHEMBL28116554 | 0.69 | HTR2A (0.35) | BRD4CCL2ATMMEN1KMT2A | |
| SCHEMBL4784825 | 0.69 | CYP2D6 (0.35) | BRD4CCL2EDNRAATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |