SCHEMBL6604766

SCHEMBL6604766

Cn1ncc(C#Cc2ccc(C(F)(F)F)cc2)c1CC(=O)O

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 4/20 0.48
EGLN1 Q9GZT9 1/20 0.42
FFAR1 O14842 3/20 0.37
PTPN1 P18031 2/20 0.37
PTPN6 P29350 2/20 0.37
PTPN11 Q06124 2/20 0.37
AGBL2 Q5U5Z8 1/20 0.36
ACACB O00763 1/20 0.36
FLT1 P17948 1/20 0.35
KDR P35968 1/20 0.35
PSEN1 P49768 1/20 0.35
PSEN2 P49810 1/20 0.35
APH1B Q8WW43 1/20 0.35
NCSTN Q92542 1/20 0.35
APH1A Q96BI3 1/20 0.35
PSENEN Q9NZ42 1/20 0.35
PTGES O14684 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6605540 0.84 PTGDR2 (0.37) PTGDR2EGLN1PTPN1PTPN6PTPN11
SCHEMBL14937930 0.74 MEN1 (0.41)
SCHEMBL14938139 0.73 CA12 (0.48)
SCHEMBL14938295 0.72 CA1 (0.44) PTPN6FLT1KDR
SCHEMBL14938278 0.71 KIF11 (0.38)
SCHEMBL14937812 0.71 CA12 (0.43)
SCHEMBL4359176 0.71 POLB (0.39)
SCHEMBL14938305 0.71 PDE2A (0.41)
SCHEMBL14937804 0.70 PDE2A (0.33) PTGDR2EGLN1
SCHEMBL14937750 0.69 CA2 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1219173-B1 INSECTICIDES AND ACARICIDES AGRO KANESHO CO LTD (JP) 2004-06-16 EP disclosed
US-20020156115-A1 Insecticidal and acaricidal composition, and methods of using the same AGRO-KANESHO CO., LTD. (JP) 2002-10-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020156115-A1 Insecticidal and acaricidal composition, and methods of using the same GSTO1, CBR3, CBR1 PTGDR2 1223/4885EGLN1 191/4885FFAR1 1369/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.