Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.70 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.69 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.69 |
| ▸ | CA2 | P00918 | 3/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL336262 | 0.83 | SIRT6 (1.00) | ADRB1SIRT6ALDH1A1MAPTKDM4E | |
| SCHEMBL7526992 | 0.83 | SIRT6 (1.00) | ADRB1SIRT6ALDH1A1MAPTKDM4E | |
| SCHEMBL18553766 | 0.82 | HTR6 (1.00) | HTR6ADRB1ALDH1A1MAPTMEN1 | |
| SCHEMBL18553746 | 0.82 | HTR6 (0.89) | HTR6ADRB1CA2CA1CA9 | |
| Hydrogen Sulfide SCHEMBL28002215 | 0.82 | SIRT6 (0.96) | ADRB1SIRT6ALDH1A1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL1814630 | 0.82 | SIRT6 (0.96) | ADRB1SIRT6ALDH1A1MAPTKDM4E | |
| SCHEMBL6152151 | 0.82 | SIRT6 (0.96) | ADRB1SIRT6ALDH1A1MAPTKDM4E | |
| SCHEMBL1496058 | 0.82 | SIRT6 (0.96) | ADRB1SIRT6ALDH1A1MAPTKDM4E | |
| SCHEMBL6151805 | 0.82 | SIRT6 (0.96) | ADRB1SIRT6ALDH1A1MAPTRECQL | |
| Hydrochloric Acid SCHEMBL18553777 | 0.81 | HTR6 (0.86) | HTR6ADRB1CA2CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729455-B1 | INDOLE-DERIVED AZYLPIPERAZINES AS LIGANDS FOR 5HT1-LIKE RECEPTORS 5HT1B AND 5HT1D | PF MEDICAMENT (FR) | 2004-09-08 | — | — | EP | disclosed |
| EP-0729455-A1 | INDOLE-DERIVED AZYLPIPERAZINES AS LIGANDS FOR 5HT1-LIKE RECEPTORS 5HT1B AND 5HT1D | PIERRE FABRE MEDICAMENT (FR) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014004-A1 | INDOLE-DERIVED AZYLPIPERAZINES AS LIGANDS FOR 5HT1-LIKE RECEPTORS 5HT1B AND 5HT1D | PIERRE FABRE MEDICAMENT (FR) | 1995-05-26 | — | — | WO | disclosed |