Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 0.45 |
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | MIF | P14174 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | BACH1 | O14867 | 1/20 | 0.37 |
| ▸ | MAFK | O60675 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15269270 | 0.88 | TRPA1 (0.39) | TRPA1NAAAPAOXSIGMAR1MIF | |
| SCHEMBL31528856 | 0.83 | HRH3 (0.46) | TRPA1NAAASIGMAR1MIFLMNA | |
| SCHEMBL3997403 | 0.82 | HRH3 (0.50) | TRPA1NAAASIGMAR1MIFLMNA | |
| SCHEMBL24162861 | 0.80 | PAOX (0.43) | PAOXSIGMAR1ALDH1A1TP53CSNK2A2 | |
| SCHEMBL24162864 | 0.80 | PAOX (0.39) | PAOXSIGMAR1ALDH1A1CSNK2A2CSNK2B | |
| SCHEMBL1456965 | 0.78 | KEAP1 (0.48) | NAAASIGMAR1MIFALDH1A1LMNA | |
| SCHEMBL3997328 | 0.78 | HRH3 (0.50) | TRPA1NAAAMIFALDH1A1LMNA | |
| SCHEMBL4392338 | 0.76 | PAOX (0.50) | PAOXSIGMAR1ALDH1A1CSNK2A2CSNK2B | |
| SCHEMBL4002648 | 0.76 | HRH3 (0.54) | TRPA1NAAAMIFLMNAKEAP1 | |
| Isothiocyanate SCHEMBL22394167 | 0.74 | SMN1; SMN2 (0.44) | NAAASIGMAR1ALDH1A1LMNAKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040210063-A1 | Novel 2,4-diaminothiazole derivatives | NOVO NORDISK A/S (DK) | 2004-10-21 | — | — | US | disclosed |
| EP-1417188-A1 | NOVEL 2,4-DIAMINOTHIAZOLE DERIVATIVES | Novo Nordisk A/S (DK) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003011843-A1 | NOVEL 2,4-DIAMINOTHIAZOLE DERIVATIVES | NOVO NORDISK A/S (DK) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040210063-A1 | Novel 2,4-diaminothiazole derivatives | GSK3B, GSK3A, GYS2 | TRPA1 3213/4885NAAA 3669/4885PAOX 1676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.