SCHEMBL6604889

SCHEMBL6604889

COc1nn(-c2ccc(NC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2)c(=O)o1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LPL P06858 1/20 0.72
LIPC P11150 1/20 0.72
LIPE Q05469 1/20 0.72
ABHD16A O95870 1/20 0.52
HDAC3 O15379 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
MGLL Q99685 4/20 0.48
FAAH O00519 3/20 0.48
MAPT P10636 5/20 0.46
ABCG2 Q9UNQ0 1/20 0.45
ORAI1 Q96D31 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
POLB P06746 1/20 0.44
RHOC P08134 1/20 0.43
RHOA P61586 1/20 0.43
THRB P10828 2/20 0.43
CRACR2A Q9BSW2 1/20 0.42
TP53 P04637 1/20 0.41
ABHD6 Q9BV23 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6602316 0.84 LPL (0.64) LPLLIPCLIPEABHD16AMGLL
SCHEMBL7047919 0.84 LPL (1.00) LPLLIPCLIPEABHD16AHDAC3
SCHEMBL6601943 0.81 LPL (0.72) LPLLIPCLIPEABHD16AMGLL
SCHEMBL7044266 0.80 LPL (0.70) LPLLIPCLIPEABHD16AMGLL
SCHEMBL7042468 0.79 LPL (0.60) LPLLIPCLIPEABHD16AMGLL
SCHEMBL6602780 0.78 LPL (0.74) LPLLIPCLIPEABHD16AMGLL
SCHEMBL6603513 0.78 LPL (0.64) LPLLIPCLIPEABHD16AMGLL
SCHEMBL6603718 0.77 LPL (0.69) LPLLIPCLIPEABHD16AMGLL
SCHEMBL6600553 0.77 LPL (0.62) LPLLIPCLIPEABHD16AMGLL
SCHEMBL6602937 0.76 ABHD16A (0.60) LPLLIPCLIPEABHD16AMGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1263745-B1 SUBSTITUTED 3-PHENYL-5-ALKOXI-1,3,4-OXDIAZOL-2-ONE AND USE THEREOF FOR INHIBITING HORMONE-SENSITIVE LIPASE AVENTIS PHARMA GMBH (DE) 2004-05-19 EP disclosed