Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1878848 | 1.00 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10PLK1ACP3 | |
| SCHEMBL27507947 | 1.00 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10PLK1ACP3 | |
| SCHEMBL27702983 | 0.84 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10PLK1ACP3 | |
| SCHEMBL1471745 | 0.84 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10PLK1ACP3 | |
| SCHEMBL28546281 | 0.84 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10PLK1ACP3 | |
| SCHEMBL27479791 | 0.83 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10PLK1ACP3 | |
| SCHEMBL3004207 | 0.79 | ALDH1A1 (0.48) | KDM4EALDH1A1HSD17B10ACP3GAA | |
| SCHEMBL6375660 | 0.79 | ALDH1A1 (0.48) | KDM4EALDH1A1HSD17B10ACP3GAA | |
| SCHEMBL1748476 | 0.79 | ALDH1A1 (0.48) | KDM4EALDH1A1HSD17B10ACP3GAA | |
| SCHEMBL4592424 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10PLK1ACP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699074-B1 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-11-13 | — | — | EP | claimed |
| US-5672582-A | ANTICOAGULANTS; 4-SUBSTITUTED CYCLOHEXYLAMINE DERIVATIVES | MERCK & CO., INC. (US) | 1997-09-30 | — | — | US | claimed |
| WO-1996011697-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1996-04-25 | — | — | WO | claimed |
| US-20120045393-A1 | LHRH-II PEPTIDE ANALOGS | BRACCO IMAGING SPA (IT) | 2012-02-23 | — | — | US | disclosed |
| WO-2010107832-A1 | LHRH-II PEPTIDE ANALOGS | BRACCO IMAGING SPA (IT) | 2010-09-23 | — | — | WO | disclosed |
| US-5672582-A | ANTICOAGULANTS; 4-SUBSTITUTED CYCLOHEXYLAMINE DERIVATIVES | MERCK & CO., INC. (US) | 1997-09-30 | — | — | US | disclosed |
| WO-1996011697-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1996-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120045393-A1 | LHRH-II PEPTIDE ANALOGS | LHCGR, GNRHR, FSHR | KDM4E 1786/4885ALDH1A1 4273/4885HSD17B10 711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.