Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12138418 | 0.86 | ALDH1A1 (0.42) | POLBALDH1A1SMN1; SMN2MAPTREN | |
| SCHEMBL3092881 | 0.84 | CACNA1B (0.36) | ALDH1A1SMN1; SMN2RENHTTMEN1 | |
| SCHEMBL4705517 | 0.81 | KDM4E (0.41) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL2635104 | 0.81 | POLB (0.50) | POLBALDH1A1SMN1; SMN2HTTRAB9A | |
| SCHEMBL1750883 | 0.81 | TSHR (0.44) | POLBALDH1A1SMN1; SMN2MAPTREN | |
| SCHEMBL662970 | 0.80 | ALDH1A1 (0.46) | POLBALDH1A1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL10186629 | 0.80 | KDM4E (0.39) | POLBALDH1A1SMN1; SMN2MAPTREN | |
| SCHEMBL662753 | 0.78 | ALDH1A1 (0.49) | POLBALDH1A1SMN1; SMN2MAPTREN | |
| SCHEMBL1751304 | 0.78 | KDM4E (0.48) | POLBALDH1A1SMN1; SMN2MAPTREN | |
| SCHEMBL1751524 | 0.77 | TSHR (0.61) | SMN1; SMN2RENMEN1KMT2ASSTR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
| US-20100249163-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2010-09-30 | — | — | US | disclosed |
| US-20100249163-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2010-09-30 | — | — | US | disclosed |
| US-20100249163-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2010-09-30 | — | — | US | disclosed |
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
| WO-2009070869-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-06-11 | — | — | WO | disclosed |
| WO-2007009250-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | POLB 2865/4885ALDH1A1 2104/4885SMN1; SMN2 4657/4885 |
| US-20100249163-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | POLB 1615/4885ALDH1A1 1125/4885SMN1; SMN2 4691/4885 |
| US-20090281103-A1 | Renin Inhibitors | REN, ACE, AGT | POLB 2408/4885ALDH1A1 2078/4885SMN1; SMN2 4550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.