Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.47 |
| ▸ | EBP | Q15125 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606686 | 0.94 | PDE4B (0.42) | SIGMAR1EBPTMEM97 | |
| SCHEMBL6606488 | 0.84 | CYP11B1 (0.48) | SIGMAR1EBPTMEM97CYP11B1CYP11B2 | |
| SCHEMBL6606792 | 0.83 | SIGMAR1 (0.47) | SIGMAR1EBPTMEM97CYP11B1CYP11B2 | |
| SCHEMBL8730444 | 0.80 | SIGMAR1 (0.63) | SIGMAR1EBPTMEM97 | |
| SCHEMBL6606573 | 0.80 | PDE3B (0.36) | — | |
| SCHEMBL6610798 | 0.77 | PDE4A (0.48) | — | |
| SCHEMBL6612948 | 0.77 | CHEK1 (0.45) | — | |
| SCHEMBL6608302 | 0.76 | KDM4E (0.36) | — | |
| SCHEMBL6606500 | 0.76 | PDE4D (0.44) | SIGMAR1EBPTMEM97 | |
| SCHEMBL6606602 | 0.72 | PDE4B (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |