Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6611559 | 0.85 | ALDH1A1 (0.42) | CHEK1CYP4F2CYP4A11ALDH1A1KMT2A | |
| SCHEMBL6606145 | 0.84 | ALDH1A1 (0.48) | CHEK1CYP4F2CYP4A11ALDH1A1KMT2A | |
| SCHEMBL6606573 | 0.77 | PDE3B (0.36) | — | |
| SCHEMBL6605638 | 0.77 | SIGMAR1 (0.47) | — | |
| SCHEMBL6608302 | 0.74 | KDM4E (0.36) | ALDH1A1KMT2AKDM4EMEN1LMNA | |
| SCHEMBL6584988 | 0.73 | CHEK1 (0.41) | CHEK1CYP4F2CYP4A11ALDH1A1HPGD | |
| SCHEMBL6606686 | 0.73 | PDE4B (0.42) | — | |
| SCHEMBL6611068 | 0.71 | HPGD (0.40) | CHEK1CYP4F2CYP4A11ALDH1A1KMT2A | |
| SCHEMBL6611074 | 0.71 | HPGD (0.40) | CHEK1CYP4F2CYP4A11ALDH1A1KMT2A | |
| SCHEMBL4851694 | 0.70 | HPGD (0.43) | CHEK1CYP4F2CYP4A11ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |